Wissenschaft ist eine systematische Disziplin, die Wissen in Form überprüfbarer Hypothesen und Vorhersagen aufbaut und organisiert. In der Medizin umfasst die Wissenschaft ein breites Forschungsspektrum, das von der Grundlagenforschung – das grundlegende wissenschaftliche Prinzipien umfasst – bis zur klinischen Forschung reicht, die Studien an Personen umfasst, die an klinischen Studien teilnehmen können. Innerhalb dieses Spektrums liegt die angewandte oder translationale Forschung. Die wissenschaftliche Gemeinschaft ist ein Netzwerk interagierender Wissenschaftler, die wissenschaftliche Forschung betreiben. Durch Peer-Review, Diskussionen und Debatten in Fachzeitschriften und Konferenzen wahren Wissenschaftler die Qualität der Forschungsmethodik und die Objektivität bei der Interpretation der Ergebnisse.
Forschungspreise und Drittmittel
2019
Research Award 2019, SANA GmbH, “Therapy with the neurotrophic protein S100B stimulates neuro- and synaptogenesis following experimental brain injury” € 10.000
2011
Grant sponsored by Otsuka Pharma GmbH, “Prospective study on the effect of the vasopressin 2 receptor antagonist Tolvaptan on hyponatrema following pituitary surgery” € 100.000
2008
Grant of the Marohn Foundation, “Therapy of experimental cytotoxic brain edema by AQP4 modulation through an vasopressin 1a antagonist” € 23.000
2007
Grant of the ZNS-Hannelore Kohl Stiftung, “Stimulation of neuroregeneration following brain damage by neurotrophic factors” € 50.000
2007
Fond for Science and Education, Friedrich-Alexander-University Erlangen-Nürnberg Medical School, “Effect of the exogenous application of the neurotrophic factor S100B on hippocampal neurogenesis following experimental traumatic brain injury“ € 16.500
2006
Travel grant, 26th Brasilian Congress of Neurosurgery and Joint Meeting with the German Society of Neurosurgery, Florianopolis, Brasil € 1.000
2006
Grant of the Section Neurosurgical Research, German Society of Neurosurgery, “Role of the glial neurotrophic factor S100B on the posttraumatic hippocampal neurogenesis in S100B transgenic and knock-out mice” € 10.000
2005
Grant of the Section Research, Georg-August-University Göttingen, “Therapeutic role of the astrocytic neurotrophic factor S100B on the posttraumatic hippocampal neuroregeneration” € 22.000
2004
Travel grant, National Neurotrauma Society 22nd Annual Symposium, San Diego, CA, USA $ 500
2004
AANS/CNS Section on Neurotrauma and Critical Care 2004, Synthes Award for Research on Brain and Craniofacial Injury $ 5.000
2001
Travel grant, German Society of Intensive Care Medicine (DIVI) € 5.000
ResearchGate
www.researchgate.net/profile/Andrea_Kleindienst
Ausgewählte Publikationen
2024
Prendi K, Burgmann N, Röckelein V, Ibisi R, Buchfelder M, Gonçalves CA, Kleindienst A: The fractional S100B Excretion is attenuated following neurotrauma suggesting an innate conservation system for neurotrophic proteins. J Surg 9:11121. (4.99)
2022
Rodrigues L, Wartchow KM, Buchfelder M, de Souza DO, Gonçalves CA, Kleindienst A: Longterm increased S100B enhances hippocampal progenitor cell proliferation in a transgenic mouse model. Int J Mol Sci 23(17):9600. DOI:10.3390/ijms23179600 (5.6)
2021
Wartchow KM, Schmid B, Tripal P, Stadlbauer A, Buchfelder M, Gonçalves CA, Kleindienst A. Reversing the Warburg effect by promoting oxidative phosphorylation reduces glioblastoma growth as assessed by two-photon microscopy. Cells 10:556. DOI:10.3390/cells10030556 (4.83)
2016
Kleindienst A, Hannon MJ, Buchfelder M, Verbalis JG: Hyponatremia in neurotrauma: The role of vasopressin. J Neurotrauma 33(7):615-24. DOI:10.1089/neu.2015.3981 (5.19)
2013
Mendelow AD, Gregson BA, Rowan EN, Murray GD, Gholkar A, Mitchell PM; STICH II Investigators: Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial. Lancet 382(9890):397-408. DOI:10.1016/S0140-6736(13)60986-1 (39.06)
2010
Fazzina G, Amorini AM, Marmarou C, Fukui S, Okuno K, Glisson R, Marmarou A, Kleindienst A: The PKC activator phorbol myristate acetate decreases brain edema by AQP4 down-regulation following middle cerebral artery occlusion in the rat. J Neurotrauma 27(2):453-61. DOI:10.1089/neu.2008.0782 (5.19)
2009
Kleindienst A, Brabant G, Bock C, Maser-Gluth C, Buchfelder M: Neuroendocrine function following traumatic brain injury and subsequent intensive care treatment: A prospective longitudinal evaluation. J Neurotrauma 26(9):1435-46. DOI:10.1089/neu.2008.0601 (5.19)
2005
Kleindienst A, Tolias CM, Corwin FD, Müller C, Marmarou A, Fatouros P, Bullock MR: Assessment of cerebral S100B levels by proton magnetic resonance spectroscopy after lateral fluid percussion injury in the rat. J Neurosurg 102(6):1115-21. DOI:10.3171/jns.2005.102.6.1115 (3.148)
Kleindienst A, McGinn M, Harvey HB, Collelo RJ, Hamm JR, Bullock MR: Enhanced hippocampal neurogenesis by intraventricular S100B infusion is associated with improved cognitive recovery after traumatic brain injury. J Neurotrauma 22(6):645-55. DOI:10.1089/neu.2005.22.645 (5.19)
2004
Kleindienst A, Hildebrandt G, Kroemer AS, Franke G, Gaab MR, Landgraf R: Hypothalamic neuropeptide release after experimental subarachnoid hemorrhage. In-vivo microdialysis study. Acta Neurol Scand 109(5):361-368. DOI:10.1046/j.1600-0404.2003.00245.x (3.126)
2003
Kleindienst A, Harvey HB, Mater E, Bronst J, Flack J, Herenz K, Haupt WF, Schoen R: Early antithrombotic prophylaxis with low molecular weight heparin in neurosurgery. Acta Neurochir 145(12):1085-1091. DOI:10.1007/s00701-003-0142-y (2.122)
1998
Kleindienst A, Hamm B, Lanksch WR: Carpal tunnel syndrome. Staging of median nerve compression by MR imaging. J Magn Res Imag 8:1119-1125. DOI:10.1002/jmri.1880080518 (2.57)